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Module Overview

The Liquid Batching and Formulation Process Module is an automated, end-to-end solution designed to achieve precise weighing, mixing, temperature control, and transportation of liquid/semi-fluid raw materials. Through intelligent process control, it ensures compliance with GMP, FDA, ISPE, and other industry standards, meeting production requirements for high precision, traceability, and contamination-free operations.

Core Components

Raw Material Storage & Transfer Module

Multi-capacity tanks (50L–5000L) with nitrogen blanketing for oxidation prevention

Sanitary diaphragm pumps/screw pumps with piping systems

Weighing & Batching Module

Modular weighing units (independent or centralized), supporting multi-component simultaneous batching

Explosion-proof design for handling flammable/combustible chemical materials

Mixing & Reactor Vessel

Integrated vessel with sight glass, sampling valve, and breather filter

Optional vacuum defoaming and in-line filtration (0.22μm sterilization-grade)

Automation Control System

PLC/HMI interface with preloaded standardized process recipes

OPC-UA/Modbus protocol support for seamless integration with MES/ERP systems

Auxiliary Systems

Purified water (PW) and water-for-injection (WFI) supply units

Waste liquid/gas recovery and treatment systems

Temperature control modules (TCU)

Key Process Control Points

Precision Weighing & Dosing

●High-precision load cells (±0.1% accuracy) with loss-in-weight/gain-in-weight technologies

●Cross-contamination prevention: Independent weighing modules, closed feeding ports, dust collection systems

●Auto-calibration and error compensation for consistent ingredient ratios

Dynamic Mixing & Homogenization

● Multi-stage agitation (paddle/magnetic/high-shear emulsification) for varying viscosities

● Real-time uniformity monitoring (conductivity, pH, temperature feedback)

● Laminar/turbulent flow switching to minimize bubbles (for injectable solutions)

Temperature & Process Parameter Control

● Jacketed vessel design with heating/cooling (PID temperature control ±0.5°C)

● In-line monitoring: Temperature, pressure, level, turbidity, dissolved oxygen (for biopharma)

Cleaning & Sterilization (CIP/SIP)

● Automated clean-in-place (CIP) and steam-in-place (SIP) for pipelines and vessels

● 316L stainless steel construction, Ra≤0.6μm surface roughness (ASME BPE compliant)

Data Traceability & Compliance

● SCADA-integrated batch data recording (e-signature, audit trail)

● Fault alarms and automatic shutdown (role-based access control)

Industry Applications

Pharmaceutical Industry

Large-volume parenteral solution preparation, oral liquid batching, vaccine adjuvant mixing, cell culture media formulation

Chemical Industry

Paint dispersion, adhesive synthesis, reaction solution preparation, chemical compounding

Biotechnology

Fermentation broth feeding, protein purification buffer preparation

Food & Beverage

Additive blending, liquid formulation systems

Core Advantages

High Efficiency & Precision

30% reduction in batch processing time, formulation error ≤0.5%

Safety & Compliance

Compliant with 21 CFR Part 11 and GMP Annex 11 data integrity requirements

Flexibility & Scalability

Modular design for capacity expansion and process adaptation

Service Support

Customized Validation Services

IQ/OQ/PQ, FAT/SAT validation protocols

Remote Monitoring & Maintenance

IoT-enabled preventive maintenance and real-time diagnostics

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