Oil phase tank with magnetic stirring + nitrogen blanketing (anti-oxidation)
Water phase tank with high-speed dispersion + heating (dissolves thickeners/emulsifiers)
The Vacuum Emulsification Process Module achieves efficient mixing and stable emulsification of oil and water phases through vacuum deaeration, high-shear homogenization, and precise temperature control, producing uniform and stable emulsions or creams. The system enables fully closed production from pre-mixing, homogenization, deaeration, to filling, compliant with GMP, ISO 22716, and FDA 21 CFR Part 211 standards, ideal for sterile or high-active-ingredient formulations.
● Precise vacuum adjustment (-0.08~-0.1 MPa), ≥95% deaeration efficiency, eliminating bubbles to prevent oxidation or filling defects
● Online foam sensors linked to vacuum pumps for dynamic defoaming
● Multi-stage homogenizer control (rotor-stator design, 1000–10000 rpm adjustable), D90 particle size ≤5μm (nanoemulsions: 100–500 nm)
● Real-time shear energy monitoring (torque sensors) to prevent localized overheating and ingredient degradation (e.g., pharmaceutical creams)
● Jacketed emulsification vessel (double/triple layers), PID temperature control (±0.5°C), rapid heating/cooling (oil melting + water phase dissolution), thermal fluid/ice-water circulation for high-viscosity materials (e.g., high-wax-content creams)
● Online viscometer+ conductivity meter to monitor phase transition, auto-adjust stirring speed and homogenization intensity
● Closed-loop pH control (acid/alkali auto-dosing) for formulation stability (e.g., personal care products pH 5.5–6.5)
● Full CIP/SIP system (acid/alkali cleaning + pure steam sterilization), dead-leg residue ≤0.1%
● 316L stainless steel, Ra ≤0.4μm mirror finish, compliant with 3D-ASTM E2700 cleanliness standards (pharmaceutical grade)
● Automated electronic batch records with critical parameters (vacuum level, homogenization time, temperature curves)
● Role-based access + audit trails aligned with EU GMP Annex 11 data integrity requirements
Creams, lotions, sunscreens
Shampoos, serums, body washes
Topical ointments, nanoemulsions, softgel capsules
Specialty lubricants, electronic coating materials
Vacuum deaeration reduces emulsification time by 40%; heat recovery cuts energy use by 25%
Modular design with expandable homogenization units
ATEX explosion-proof certification (solvent-based formulations), sterile-grade design (pharmaceutical ointments)
Emulsification trials and validation documentation
Explosion-proof (chemical), sterile (pharmaceutical), lab-scale pilot machines (R&D)
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